Unknown

Dataset Information

0

Endogenous retroviruses in the origins and treatment of cancer.


ABSTRACT: Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer. As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate expression from gene networks, including those underpinning embryogenesis and immune cell function. ERV activation can promote an interferon response, a phenomenon termed viral mimicry. Although ERV expression is associated with cancer, and provisionally with autoimmune and neurodegenerative diseases, ERV-mediated inflammation is being explored as a way to sensitize tumors to immunotherapy. Here we review ERV co-option in development and innate immunity, the aberrant contribution of ERVs to tumorigenesis, and the wider biomedical potential of therapies directed at ERVs.

SUBMITTER: Jansz N 

PROVIDER: S-EPMC8108463 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC10115647 | biostudies-literature
| S-EPMC1187282 | biostudies-literature
| S-EPMC2258715 | biostudies-literature
| S-EPMC10108094 | biostudies-literature
| S-EPMC7402293 | biostudies-literature
| S-EPMC2748012 | biostudies-literature
| S-EPMC8067472 | biostudies-literature
| S-EPMC7829834 | biostudies-literature
| S-EPMC99133 | biostudies-literature
| S-EPMC224999 | biostudies-literature