Ontology highlight
ABSTRACT:
SUBMITTER: Bourguet P
PROVIDER: S-EPMC8113232 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Bourguet Pierre P Picard Colette L CL Yelagandula Ramesh R Pélissier Thierry T Lorković Zdravko J ZJ Feng Suhua S Pouch-Pélissier Marie-Noëlle MN Schmücker Anna A Jacobsen Steven E SE Berger Frédéric F Mathieu Olivier O
Nature communications 20210511 1
In flowering plants, heterochromatin is demarcated by the histone variant H2A.W, elevated levels of the linker histone H1, and specific epigenetic modifications, such as high levels of DNA methylation at both CG and non-CG sites. How H2A.W regulates heterochromatin organization and interacts with other heterochromatic features is unclear. Here, we create a h2a.w null mutant via CRISPR-Cas9, h2a.w-2, to analyze the in vivo function of H2A.W. We find that H2A.W antagonizes deposition of H1 at hete ...[more]