Ontology highlight
ABSTRACT:
SUBMITTER: Choi J
PROVIDER: S-EPMC8828055 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Choi Jaemyung J Lyons David B DB Zilberman Daniel D
eLife 20211201
Flowering plants utilize small RNA (sRNA) molecules to guide DNA methyltransferases to genomic sequences. This RNA-directed DNA methylation (RdDM) pathway preferentially targets euchromatic transposable elements. However, RdDM is thought to be recruited by methylation of histone H3 at lysine 9 (H3K9me), a hallmark of heterochromatin. How RdDM is targeted to euchromatin despite an affinity for H3K9me is unclear. Here, we show that loss of histone H1 enhances heterochromatic RdDM, preferentially a ...[more]