Ontology highlight
ABSTRACT:
SUBMITTER: Polavaram NS
PROVIDER: S-EPMC8121836 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Polavaram Navatha Shree NS Dutta Samikshan S Islam Ridwan R Bag Arup K AK Roy Sohini S Poitz David D Karnes Jeffrey J Hofbauer Lorenz C LC Kohli Manish M Costello Brian A BA Jimenez Raffael R Batra Surinder K SK Teply Benjamin A BA Muders Michael H MH Datta Kaustubh K
Bone research 20210514 1
Understanding the role of neuropilin 2 (NRP2) in prostate cancer cells as well as in the bone microenvironment is pivotal in the development of an effective targeted therapy for the treatment of prostate cancer bone metastasis. We observed a significant upregulation of NRP2 in prostate cancer cells metastasized to bone. Here, we report that targeting NRP2 in cancer cells can enhance taxane-based chemotherapy with a better therapeutic outcome in bone metastasis, implicating NRP2 as a promising th ...[more]