Crown-Like Structures in Breast Adipose Tissue: Early Evidence and Current Issues in Breast Cancer.

ABSTRACT: Obesity is an established risk factor for postmenopausal breast cancer and has been linked to worse breast cancer prognosis, most clearly for hormone receptor-positive breast cancers. The underlying mechanisms of the obesity-breast cancer association are not fully understood, but growing evidence points to the breast adipose tissue microenvironment playing an important role. Obesity-induced adipose tissue dysfunction can result in a chronic state of low-grade inflammation. Crown-like structures of the breast (CLS-B) were recently identified as a histologic marker of local inflammation. In this review, we evaluate the early evidence of CLS-B in breast cancer. Data from preclinical and clinical studies show that these inflammatory lesions within the breast are associated with local NF-κB act

SUBMITTER: Maliniak ML 

PROVIDER: S-EPMC8124644 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature