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Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer.

ABSTRACT: BACKGROUND:Crown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data are sparse, particularly in multi-racial populations. METHODS:We assessed specimens for CLS-B from 174 African-American and 168 White women with stage I-III breast cancer treated by mastectomy. Benign breast tissue from an uninvolved quadrant was immunohistochemically stained for CD68 to determine CLS-B presence and density (per cm2 of adipose tissue). Demographic and lifestyle factors, collected via medical record review, were analyzed for associations with CLS-B using logistic regression. Multivariable Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between CLS-B and overall (OS) or progression-free (PFS) survival. RESULTS:Detection of any CLS-B was similar between African-American (32%) and White (29%) patients with no evidence of an association between race and CLS-B in multivariable models (OR?=?0.82, 95% CI?=?0.49-1.36). Detection of CLS-B was associated with obesity (OR?=?4.73, 95% CI?=?2.48-9.01) and age???60?years at diagnosis (OR?=?1.78, 95% CI?=?0.99-3.21). There was some evidence of associations with parity and current smoking status. Detection of CLS-B was not associated with OS (HR?=?1.02, 95% CI?=?0.55-1.87) or PFS (HR?=?0.99, 95% CI?=?0.59-1.67). CONCLUSIONS:Our results show a strong, positive association between BMI and CLS-B in non-tumor tissue similar to previous findings. Detection of CLS-B did not vary by race and was not associated with worse OS or PFS.

SUBMITTER: Maliniak ML

PROVIDER: S-EPMC7298873 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer.

Maliniak Maret L ML Cheriyan Aswathy Miriam AM Sherman Mark E ME Liu Yuan Y Gogineni Keerthi K Liu Jiaqi J He Jiabei J Krishnamurti Uma U Miller-Kleinhenz Jasmine J Ashiqueali Ryan R He Jinjing J Yacoub Rami R McCullough Lauren E LE

Breast cancer research : BCR 20200617 1

<h4>Background</h4>Crown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data are sparse, particularly in multi-racial populations.<h4>Methods</h4>We assessed specimens for CLS-B from 174 African-American and 168 White women with stage I-III breast cancer treated by mastectomy. Benign breast tissue from an uninvolved quadrant was immunohistochemical ...[more]

PMID: 32552729

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Project description:African Americans have a disproportionate burden of aggressive young-onset breast cancer. Genomic testing for inherited predisposition to breast cancer is increasingly common in clinical practice, but comprehensive mutation profiles remain unknown for most minority populations. We evaluated 289 patients who self-identified as African American with primary invasive breast cancer and with personal or family cancer history or tumor characteristics associated with high genetic risk for all classes of germline mutations in known breast cancer susceptibility genes using a validated targeted capture and multiplex sequencing approach. Sixty-eight damaging germline mutations were identified in 65 (22 %, 95 % CI 18-28 %) of the 289 subjects. Proportions of patients with unequivocally damaging mutations in a breast cancer gene were 26 % (47/180; 95 % confident interval [CI] 20-33 %) of those with breast cancer diagnosis before age 45; 25 % (26/103; 95 % CI 17-35 %) of those with triple-negative breast cancer (TNBC); 29 % (45/156; 95 % CI 22-37 %) of those with a first or second degree relative with breast cancer before age 60 or with ovarian cancer; and 57 % (4/7; 95 % CI 18-90 %) of those with both breast and ovarian cancer. Of patients with mutations, 80 % (52/65) carried mutations in BRCA1 and BRCA2 genes and 20 % (13/65) carried mutations in PALB2, CHEK2, BARD1, ATM, PTEN, or TP53. The mutational allelic spectrum was highly heterogeneous, with 57 different mutations in 65 patients. Of patients meeting selection criteria other than family history (i.e., with young age at diagnosis or TNBC), 48 % (64/133) had very limited information about the history of cancer in previous generations of their families. Mutations in BRCA1 and BRCA2 or another breast cancer gene occur in one in four African American breast cancer patients with early onset disease, family history of breast or ovarian cancer, or TNBC. Each of these criteria defines patients who would benefit from genomic testing and novel therapies targeting DNA repair pathways.

Dataset Information

Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer.

Publications

Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer.

Similar Datasets

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