Interleukin-31 and Pruritic Skin.
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ABSTRACT:
SUBMITTER: Furue M
PROVIDER: S-EPMC8124688 | biostudies-literature | 2021 Apr
REPOSITORIES: biostudies-literature
Publications
Interleukin-31 and Pruritic Skin.
Furue Masutaka M Furue Mihoko M
Journal of clinical medicine 20210428 9
Skin inflammation often evokes pruritus, which is the major subjective symptom in many inflammatory skin diseases such as atopic dermatitis and prurigo nodularis. Pruritus or itch is a specific sensation found only in the skin. Recent studies have stressed the pivotal role played by interleukin-31 (IL-31) in the sensation of pruritus. IL-31 is produced by various cells including T helper 2 cells, macrophages, dendritic cells and eosinophils. IL-31 signals via a heterodimeric receptor composed of ...[more]
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