ABSTRACT: A better understanding of the demands of in-game competition demands may improve coaching strategies, training designs, and injury prevention programs. However, there is limited information regarding performance analysis in professional padel. This study aimed to analyse performance indicators and their influence on match outcomes regarding sex, tournament round, and set number. The sample contained 1070 sets from 532 matches of the 2016 to 2019 World Padel Tour seasons. Variables including sex, round, game result, stroke effectiveness, and break points were registered through systematic observation. A non-parametric approach was applied to evaluate differences between sex, match outcome, and tournament round. The results showed significant differences between winners and losers regarding sex in break points (male d = 2.13, p = 0.00; female d = 2.22, p = 0.00), smash winners (male d = 0.85, p = 0.00; female d = 0.69, p = 0.00), groundstroke winners (male d = 1.01, p = 0.00; female d = 1.18, p = 0.00), volley winners (male d = 1.08, p = 0.00; female d = 0.91, p = 0.00), and errors (male d = 0.76, p = 0.00; female d = 0.65, p = 0.00). Furthermore, differences in shot effectiveness between winners and errors increased in the last set of the match and in the last round of the tournament (p < 0.05). Therefore, shot effectiveness seems to be a key factor in professional padel that distinguishes between winning and losing players. Such knowledge may have implications in the design of appropriate game strategies and specific training sessions to improve performance and to prevent sport injuries.