Dataset Information

Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study.

ABSTRACT:

Background

Gut microbiota dysbiosis is reportedly actively involved in autoimmune diseases such as type 1 diabetes mellitus (T1DM). However, the alterations in the gut microbiota and their correlation with fasting blood glucose (FBG) in Chinese children with T1DM remain unclear.

Aim

To investigate alterations in the gut microbiota in Chinese children with T1DM and their associations with clinical indicators.

Methods

Samples from 51 children with T1DM and 47 age-matched and gender-matched healthy controls were obtained, to explore the structural and functional alterations in the fecal microbiota. The V3-V4 regions of the 16S rRNA gene were sequenced on a MiSeq instrument, and the association with FBG were analyzed.