Ontology highlight
ABSTRACT:
SUBMITTER: Pedrelli M
PROVIDER: S-EPMC8131316 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Pedrelli Matteo M Parini Paolo P Kindberg Jonas J Arnemo Jon M JM Bjorkhem Ingemar I Aasa Ulrika U Westerståhl Maria M Walentinsson Anna A Pavanello Chiara C Turri Marta M Calabresi Laura L Öörni Katariina K Camejo Gérman G Fröbert Ole O Hurt-Camejo Eva E
Journal of lipid research 20210311
Plasma cholesterol and triglyceride (TG) levels are twice as high in hibernating brown bears (Ursus arctos) than healthy humans. Yet, bears display no signs of early stage atherosclerosis development when adult. To explore this apparent paradox, we analyzed plasma lipoproteins from the same 10 bears in winter (hibernation) and summer using size exclusion chromatography, ultracentrifugation, and electrophoresis. LDL binding to arterial proteoglycans (PGs) and plasma cholesterol efflux capacity (C ...[more]