Ontology highlight
ABSTRACT:
SUBMITTER: Sewell DK
PROVIDER: S-EPMC8132919 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Sewell Daniel K DK Penney Journey J Jay Melissa M Zhang Ying Y Paulsen Jane S JS
Journal of applied statistics 20200427 7
While there is no known cure for Huntington's disease (HD), there are early-phase clinical trials aimed at altering disease progression patterns. There is, however, no obvious single outcome for these trials to evaluate treatment efficacy. Currently used outcomes are, while reasonable, not optimal in any sense. In this paper we derive a method for constructing a composite variable via a linear combination of clinical measures. Our composite variable optimizes the signal-to-noise ratio (SNR) with ...[more]