Evidence for GRN connecting multiple neurodegenerative diseases.
Ontology highlight
ABSTRACT:
SUBMITTER: Nalls MA
PROVIDER: S-EPMC8134835 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Publications
Evidence for <i>GRN</i> connecting multiple neurodegenerative diseases.
Nalls Mike A MA Blauwendraat Cornelis C Sargent Lana L Vitale Dan D Leonard Hampton H Iwaki Hirotaka H Song Yeajin Y Bandres-Ciga Sara S Menden Kevin K Faghri Faraz F Heutink Peter P Cookson Mark R MR Singleton Andrew B AB
Brain communications 20210501 2
Previous research using genome-wide association studies has identified variants that may contribute to lifetime risk of multiple neurodegenerative diseases. However, whether there are common mechanisms that link neurodegenerative diseases is uncertain. Here, we focus on one gene, <i>GRN</i>, encoding progranulin, and the potential mechanistic interplay between genetic risk, gene expression in the brain and inflammation across multiple common neurodegenerative diseases. We utilized genome-wide as ...[more]
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