Ontology highlight
ABSTRACT:
SUBMITTER: Cai CX
PROVIDER: S-EPMC8138758 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Cai Cindy X CX Schneck Nicole A NA Ivleva Vera B VB Gulla Krishana K Zhang Yaqiu Y Gowetski Daniel D Paula Lei Q Q
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20200319
A fusion peptide mimicking a part of the sequence of HIV-1 envelope glycoprotein with an additional cysteine at its C-terminus (FP8: AVGIGAVFC) was conjugated to a carrier protein through a linker for development of an HIV-1 vaccine. Since this fusion peptide is very hydrophobic with poor solubility and can self-dimerize via a disulfide bond, co-existence of monomeric and dimeric forms presented a major challenge for residual unconjugated FP8 quantification. A reversed-phase liquid chromatograph ...[more]