Dataset Information

Interaction of CSF α-synuclein and amyloid beta in cognition and cortical atrophy.

ABSTRACT:

Introduction

Lewy body-related pathology is commonly observed at autopsy in individuals with dementia, but in vivo biomarkers for α-synucleinopathy are lacking.

Methods

Baseline cerebrospinal fluid (CSF) biomarkers, polygenic risk score (PRS) for Parkinson's disease (PRS-PD) and Alzheimer's disease (PRS-AD), longitudinal cognitive scores, and magnetic resonance imaging were measured in 217 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear mixed models were used to find the relationship of CSF biomarkers and the PRS with cognition and cortical atrophy.

Results

Higher PRS-PD and PRS-AD were associated with lower CSF α-synuclein and amyloid beta (Aβ), respectively. Lower CSF α-synuclein and the interaction of CSF α-synuclein and Aβ were associated with lower cognitive scores and global cortical atrophy most prominently in the occipital cortex.

Discussion

Lower CSF α-synuclein could be a biomarker for α-synucleinopathy, and the simultaneous evaluation of CSF biomarkers for AD and CSF α-synuclein could reveal the independent and interactive effects on cognition and cortical atrophy.

SUBMITTER: Lee YG

PROVIDER: S-EPMC8140203 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

Interaction of CSF α-synuclein and amyloid beta in cognition and cortical atrophy.

Lee Young-Gun YG Jeon Seun S Kang Sung Woo SW Park Mincheol M Baik Kyoungwon K Yoo Han Soo HS Chung Seok Jong SJ Jeong Seong Ho SH Jung Jin Ho JH Lee Phil Hyu PH Sohn Young Ho YH Evans Alan C AC Ye Byoung Seok BS

Alzheimer's & dementia (Amsterdam, Netherlands) 20210521 1

<h4>Introduction</h4>Lewy body-related pathology is commonly observed at autopsy in individuals with dementia, but in vivo biomarkers for α-synucleinopathy are lacking.<h4>Methods</h4>Baseline cerebrospinal fluid (CSF) biomarkers, polygenic risk score (PRS) for Parkinson's disease (PRS-PD) and Alzheimer's disease (PRS-AD), longitudinal cognitive scores, and magnetic resonance imaging were measured in 217 participants from the Alzheimer's Disease Neuroimaging Initiative. Linear mixed models were ...[more]

PMID: 34046519

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Dataset Information

Interaction of CSF α-synuclein and amyloid beta in cognition and cortical atrophy.

Introduction

Methods

Results

Discussion

Publications

Interaction of CSF α-synuclein and amyloid beta in cognition and cortical atrophy.

Similar Datasets

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