Hippocampal blood-brain barrier permeability is related to the APOE4 mutation status of elderly individuals without dementia.

ABSTRACT: Blood-brain barrier (BBB) disruption, modulated by APOE4 mutation, is implicated in the pathogenesis of cognitive decline. We determined whether BBB permeability differed according to cognitive functioning and APOE4 status in elderly subjects without dementia. In this prospective study, 33 subjects with mild cognitive impairment (MCI) and 33 age-matched controls (normal cognition [NC]) underwent 3 T brain magnetic resonance imaging. The Patlak model was used to calculate tissue permeability (K_trans). A region-of interest analysis of K_trans was performed to compare relevant brain regions. Effects of K_trans on cognitive functioning were evaluated with linear regression analysis adjusted for confounding factors. NC and MCI groups did not differ in terms of vas

SUBMITTER: Moon WJ 

PROVIDER: S-EPMC8142140 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature