Claudin h Is Essential for Hair Cell Morphogenesis and Auditory Function in Zebrafish.

ABSTRACT: Hereditary hearing loss caused by defective hair cells is one of the most common congenital diseases, whose nosogenesis is still unclear because many of the causative genes remain unidentified. Claudins are one kind of transmembrane proteins that constitute the most important components of the tight junctions and paracellular barrier and play important roles in neurodevelopment. In this study, we investigated the function of claudin h in morphogenesis and auditory function of the hair cell in zebrafish. The results of in situ hybridization showed that claudin h was specifically localized in the otic vesicle and neuromasts in zebrafish embryos. The deficiency of claudin h caused significant reduction of otic vesicle size and loss of utricle otolith. Moreover, the

SUBMITTER: Gong J 

PROVIDER: S-EPMC8147561 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature