Cellular lensing and near infrared fluorescent nanosensor arrays to enable chemical efflux cytometry.

ABSTRACT: Nanosensors have proven to be powerful tools to monitor single cells, achieving spatiotemporal precision even at molecular level. However, there has not been way of extending this approach to statistically relevant numbers of living cells. Herein, we design and fabricate nanosensor array in microfluidics that addresses this limitation, creating a Nanosensor Chemical Cytometry (NCC). nIR fluorescent carbon nanotube array is integrated along microfluidic channel through which flowing cells is guided. We can utilize the flowing cell itself as highly informative Gaussian lenses projecting nIR profiles and extract rich information. This unique biophotonic waveguide allows for quantified cross-correlation of biomolecular information with various physical properties and creates label-free chemica

SUBMITTER: Cho SY 

PROVIDER: S-EPMC8149711 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature