Ontology highlight
ABSTRACT:
SUBMITTER: Szulc N
PROVIDER: S-EPMC8151669 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Szulc Natalia N Gąsior-Głogowska Marlena M Wojciechowski Jakub W JW Szefczyk Monika M Żak Andrzej M AM Burdukiewicz Michał M Kotulska Malgorzata M
International journal of molecular sciences 20210512 10
CsgA is an aggregating protein from bacterial biofilms, representing a class of functional amyloids. Its amyloid propensity is defined by five fragments (R1-R5) of the sequence, representing non-perfect repeats. Gate-keeper amino acid residues, specific to each fragment, define the fragment's propensity for self-aggregation and aggregating characteristics of the whole protein. We study the self-aggregation and secondary structures of the repeat fragments of <i>Salmonella enterica</i> and <i>Esch ...[more]