A novel method for measuring absolute coronary blood flow and microvascular resistance in patients with ischaemic heart disease.

ABSTRACT:

Aims

Ischaemic heart disease is the reduction of myocardial blood flow, caused by epicardial and/or microvascular disease. Both are common and prognostically important conditions, with distinct guideline-indicated management. Fractional flow reserve (FFR) is the current gold-standard assessment of epicardial coronary disease but is only a surrogate of flow and only predicts percentage flow changes. It cannot assess absolute (volumetric) flow or microvascular disease. The aim of this study was to develop and validate a novel method that predicts absolute coronary blood flow and microvascular resistance (MVR) in the catheter laboratory.

Methods and results

A computational fluid dynamics (CFD) model was used to predict absolute coronary flow (QCFD) and coronary MVR using data f

SUBMITTER: Morris PD 

PROVIDER: S-EPMC8152717 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature