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Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery.

ABSTRACT: Microparticles with strong adherence are expected as efficient drug delivery vehicles. Herein, we presented an ingenious hydrogel microparticle recapitulating the adhesion mechanism of Boston ivy tendrils adhesive discs (AD) for durable drug delivery. The particles were achieved by replicating a silica colloidal crystal aggregates assembled in a droplet template after rapid solvent extraction. Due to their unique shape, the nanostructure, and the sticky hydrogel component, such novel microparticles exhibited prominent adhesive property to the wet tissue environment. It was demonstrated that the bioinspired microcarriers loading with dexamethasone had a good therapeutic effect for ulcerative colitis due to the strong adhesion ability for prolonging the maintenance of drug availability. These virtues make the biomimetic microparticles potentially ideal for many practical clinical applications, such as drug delivery, bioimaging, and biodiagnostics.

SUBMITTER: Cai L

PROVIDER: S-EPMC8153044 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Boston Ivy-Inspired Disc-Like Adhesive Microparticles for Drug Delivery.

Cai Lijun L Chen Guopu G Wang Yuetong Y Zhao Cheng C Shang Luoran L Zhao Yuanjin Y

Research (Washington, D.C.) 20210517

Microparticles with strong adherence are expected as efficient drug delivery vehicles. Herein, we presented an ingenious hydrogel microparticle recapitulating the adhesion mechanism of Boston ivy tendrils adhesive discs (AD) for durable drug delivery. The particles were achieved by replicating a silica colloidal crystal aggregates assembled in a droplet template after rapid solvent extraction. Due to their unique shape, the nanostructure, and the sticky hydrogel component, such novel micropartic ...[more]

PMID: 34104893

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