Ontology highlight
ABSTRACT:
SUBMITTER: Zeng Z
PROVIDER: S-EPMC8154237 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Zeng Ziyu Z Kociok-Köhn Gabriele G Woodman Timothy J TJ Rowan Michael G MG Blagbrough Ian S IS
ACS omega 20210507 19
The through-space <sup>1</sup>H NMR effect of steric compression by the lone-pair electrons of O- and N-atoms is shown in synthetic [3.3.1]oxa- and azabicycles. The electrons of the compressed proton bond are pushed away by the repulsive force generated by the lone-pair electrons of the heteroatom. There is a corresponding significant increase in the chemical shift of the compressed proton. The intensity of this deshielding effect is related to the proximity and overlap of the lone-pair or compr ...[more]