Unknown

Dataset Information

0

The 1H NMR Spectroscopic Effect of Steric Compression Is Found in [3.3.1]Oxa- and Azabicycles and Their Analogues.


ABSTRACT: The through-space 1H NMR effect of steric compression by the lone-pair electrons of O- and N-atoms is shown in synthetic [3.3.1]oxa- and azabicycles. The electrons of the compressed proton bond are pushed away by the repulsive force generated by the lone-pair electrons of the heteroatom. There is a corresponding significant increase in the chemical shift of the compressed proton. The intensity of this deshielding effect is related to the proximity and overlap of the lone-pair or compressing atom. The steric compression decreases when the lone-pair electrons of the heteroatom and the compressed proton are not directly overlapped, for example, in [4.3.1]- and [3.2.1]azabicycles. Steric compression is also caused by a proton, deuterium, or an ethyl group close in space to the compressed proton. The protonated [3.3.1]azabicycle adopts a true-boat/true-chair conformation in its crystal lattice, but in solution the conformation is true-chair/true-chair.

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC8154237 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

The <sup>1</sup>H NMR Spectroscopic Effect of Steric Compression Is Found in [3.3.1]Oxa- and Azabicycles and Their Analogues.

Zeng Ziyu Z   Kociok-Köhn Gabriele G   Woodman Timothy J TJ   Rowan Michael G MG   Blagbrough Ian S IS  

ACS omega 20210507 19


The through-space <sup>1</sup>H NMR effect of steric compression by the lone-pair electrons of O- and N-atoms is shown in synthetic [3.3.1]oxa- and azabicycles. The electrons of the compressed proton bond are pushed away by the repulsive force generated by the lone-pair electrons of the heteroatom. There is a corresponding significant increase in the chemical shift of the compressed proton. The intensity of this deshielding effect is related to the proximity and overlap of the lone-pair or compr  ...[more]

Similar Datasets

| S-EPMC7301575 | biostudies-literature
| S-EPMC11372749 | biostudies-literature
| S-EPMC6274158 | biostudies-literature
| S-EPMC1177566 | biostudies-other
| S-EPMC8938925 | biostudies-literature
| S-EPMC10170355 | biostudies-literature
| S-EPMC8644311 | biostudies-literature
| S-EPMC7445413 | biostudies-literature
| S-EPMC3116430 | biostudies-literature
| S-EPMC9453926 | biostudies-literature