Manganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditions.

ABSTRACT: In this paper, several Mn(I) complexes were applied as catalysts for the homogeneous hydrogenation of ketones. The most active precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe) (CO)₃(CH₂CH₂CH₃)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed. At room temperature, the carbonyl group was selectively hydrogenated, while the C=C bond stayed intact. At 60 °C, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed.

SUBMITTER: Weber S 

PROVIDER: S-EPMC8155567 | biostudies-literature |

REPOSITORIES: biostudies-literature