Ontology highlight
ABSTRACT:
SUBMITTER: Du Q
PROVIDER: S-EPMC7450644 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
ACS omega 20200813 33
A general and efficient method for copper-catalyzed transfer hydrogenation of isoquinolines with an oxazaborolidine-BH<sub>3</sub> complex, under mild reaction conditions, is successfully developed. A broad range of isoquinolines has been reduced to the corresponding products with 61-85% yields. The method is applied to the synthesis of biologically active tetrahydrosioquinoline alkaloid (±)-norlaudanosine in 62% yield, which is the key precursor for the preparation of (±)-laudanosine, (±)-<i>N< ...[more]