Visualizing intracellular particles and precise control of drug release using an emissive hydrazone photochrome.

ABSTRACT: The spatiotemporal control over the structure of nanoparticles while monitoring their localization in tumor cells can improve the precision of controlled drug release, thus enhancing the efficiency of drug delivery. Here, we report on a photochromic nanoparticle system (LSNP), assembled from fluorescent bistable hydrazone photoswitch-modified amphiphilic copolymers. The intrinsic emission of the hydrazone switch allows for the visualization of particle uptake, as well as their intracellular distribution. The Z → E photoswitching of the hydrazone switch within the nanoparticle leads to the expansion of the nanoparticles (i.e., drug release) accompanied by emission quenching, the degree of which can function as an internal indicator for the amount of drug released

SUBMITTER: Guo X 

PROVIDER: S-EPMC8157519 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature