Palladium-catalyzed asymmetric hydrophosphorylation of alkynes: facile access to P-stereogenic phosphinates.
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ABSTRACT: Despite the importance of P-chiral organophosphorus compounds in asymmetric catalysis, transition metal-catalyzed methods for accessing P-chiral phosphine derivatives are still limited. Herein, a catalytic enantioselective method for the synthesis of P-stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation of alkynes. This process is demonstrated for a wide range of racemic phosphinates and leads to diverse P-stereogenic alkenylphosphinates directly.
SUBMITTER: Yang Z
PROVIDER: S-EPMC8159285 | biostudies-literature |
REPOSITORIES: biostudies-literature
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