Molecular recognition of pyrazine N,N'-dioxide using aryl extended calix[4]pyrroles.

ABSTRACT: Calix[4]pyrrole (C4P)-based systems have been extensively explored as binding agents for anions and ion pairs. However, their capacity to act as molecular containers for neutral species remains underexplored. We report here the molecular recognition of pyrazine N,N'-dioxide (PZDO) using a series of aryl extended C4Ps including three α,α-diaryl substituted C4Ps (receptors 1-3), an α,β-diaryl substituted C4P (receptor 4) and an α,α,α,α-tetraaryl substituted C4P (receptor 5). Single crystal structural analyses of the 2 : 1 host-guest complexes between receptors 1-3 and PZDO revealed that the C4P subunits exist in an unusual partial cone conformation and that the PZDO guest is held within electron-rich cavities formed by the lower

SUBMITTER: Guo C 

PROVIDER: S-EPMC8159416 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature