Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
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ABSTRACT:
SUBMITTER: Merighi S
PROVIDER: S-EPMC8161210 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Alzheimer and Purinergic Signaling: Just a Matter of Inflammation?
Merighi Stefania S Poloni Tino Emanuele TE Terrazzan Anna A Moretti Eva E Gessi Stefania S Ferrari Davide D
Cells 20210520 5
Alzheimer's disease (AD) is a widespread neurodegenerative pathology responsible for about 70% of all cases of dementia. Adenosine is an endogenous nucleoside that affects neurodegeneration by activating four membrane G protein-coupled receptor subtypes, namely P1 receptors. One of them, the A<sub>2A</sub> subtype, is particularly expressed in the brain at the striatal and hippocampal levels and appears as the most promising target to counteract neurological damage and adenosine-dependent neuroi ...[more]
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