In vivo imaging reveals mature Oligodendrocyte division in adult Zebrafish.

ABSTRACT: Whether mature oligodendrocytes (mOLs) participate in remyelination has been disputed for several decades. Recently, some studies have shown that mOLs participate in remyelination by producing new sheaths. However, whether mOLs can produce new oligodendrocytes by asymmetric division has not been proven. Zebrafish is a perfect model to research remyelination compared to other species. In this study, optic nerve crushing did not induce local mOLs death. After optic nerve transplantation from olig2:eGFP fish to AB/WT fish, olig2⁺ cells from the donor settled and rewrapped axons in the recipient. After identifying these rewrapping olig2⁺ cells as mOLs at 3 months posttransplantation, in vivo imaging showed that olig2⁺ cells proliferated. Additionally, in vivo i

SUBMITTER: Zou S 

PROVIDER: S-EPMC8169745 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature