Therapeutic Targeting of Repurposed Anticancer Drugs in Alzheimer's Disease: Using the Multiomics Approach.

ABSTRACT:

Aim/hypothesis

The complexity and heterogeneity of multiple pathological features make Alzheimer's disease (AD) a major culprit to global health. Drug repurposing is an inexpensive and reliable approach to redirect the existing drugs for new indications. The current study aims to study the possibility of repurposing approved anticancer drugs for AD treatment. We proposed an in silico pipeline based on "omics" data mining that combines genomics, transcriptomics, and metabolomics studies. We aimed to validate the neuroprotective properties of repurposed drugs and to identify the possible mechanism of action of the proposed drugs in AD.

Results

We generated a list of AD-related genes and then searched DrugBank database and Therapeutic Target Database to find anticancer d

SUBMITTER: Advani D 

PROVIDER: S-EPMC8173619 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature