Ontology highlight
ABSTRACT:
SUBMITTER: McEwen JM
PROVIDER: S-EPMC8175500 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
McEwen Joseph M JM Fraser Sasha S Guir Alexxandra L Sosa ALS Dave Jaydev J Scheck Rebecca A RA
Nature communications 20210603 1
The methylglyoxal-derived hydroimidazolone isomer, MGH-1, is an abundant advanced glycation end-product (AGE) associated with disease and age-related disorders. As AGE formation occurs spontaneously and without an enzyme, it remains unknown why certain sites on distinct proteins become modified with specific AGEs. Here, we use a combinatorial peptide library to determine the chemical features that favor MGH-1. When properly positioned, tyrosine is found to play an active mechanistic role that fa ...[more]