Unknown

Dataset Information

0

Reference values for high attenuation areas on chest CT in a healthy, never-smoker, multi-ethnic sample: The MESA study.


ABSTRACT:

Background and objective

Normative values for HAA-a quantitative, CT-based measure of subclinical ILD-in healthy adults are needed to improve interpretability in clinical and research settings.

Methods

HAA was measured on full-lung CT in 3110 participants in the MESA study. Clinical prediction models were developed using a healthy never-smoker subset with normal spirometry (n = 696). RMSE on cross-validation was used as the primary criterion for model selection. Parametric and non-parametric methods were considered. z-Scores were calculated for the entire study sample. Associations between z-scores and several ILD features were estimated.

Results

In the healthy never-smoker subset, the mean age was 69 years with a range of 54-93 years. The median HAA was 4.3% with a range of 2.7-17.8%. Linear regression had better predictive performance than other methods. The final model included race, height, weight, age and sex. The standard error of the estimate was 1.62 with a cross-validated RMSE of 1.64 and an adjusted R2 of 0.139. z-Scores were associated with several ILD outcomes in adjusted models, including ILA (OR: 1.40 per z-unit; 95% CI: 1.30, 1.52), exertional dyspnoea (OR: 1.08 per z-unit; 95% CI: 1.02, 1.15) and FVC (expected increase per z-unit: -2.49; 95% CI: -2.95, - 2.03).

Conclusion

We present a reference equation and z-scores to define expected values of HAA on full-lung CT to aid HAA interpretation in middle-aged and older adults.

SUBMITTER: Easthausen I 

PROVIDER: S-EPMC8176866 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC5089905 | biostudies-literature
| S-EPMC2803123 | biostudies-other
| S-EPMC6131182 | biostudies-literature
| S-EPMC4722226 | biostudies-literature
| PRJNA1105133 | ENA
| S-EPMC4397043 | biostudies-literature
| S-EPMC6143697 | biostudies-literature
| S-EPMC8700567 | biostudies-literature
| S-EPMC6878160 | biostudies-literature
| S-EPMC5407811 | biostudies-literature