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Access to P-stereogenic compounds via desymmetrizing enantioselective bromination.

ABSTRACT: A novel and efficient desymmetrizing asymmetric ortho-selective mono-bromination of bisphenol phosphine oxides under chiral squaramide catalysis was reported. Using this asymmetric ortho-bromination strategy, a wide range of chiral bisphenol phosphine oxides and bisphenol phosphinates were obtained with good to excellent yields (up to 92%) and enantioselectivities (up to 98.5 : 1.5 e.r.). The reaction could be scaled up, and the synthetic utility of the desired P-stereogenic compounds was proved by transformations and application in an asymmetric reaction.

SUBMITTER: Huang QH

PROVIDER: S-EPMC8179578 | biostudies-literature |

REPOSITORIES: biostudies-literature

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