Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC8179593 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Chen Dongfei D Wu Yanfang Y Hoque Sharmin S Tilley Richard D RD Gooding J Justin JJ
Chemical science 20210303 14
An accurate and robust method for quantifying the levels of circulating tumor DNA (ctDNA) is vital if this potential biomarker is to be used for the early diagnosis of cancer. The analysis of ctDNA presents unique challenges because of its short half-life and ultralow abundance in early stage cancers. Here we develop an ultrasensitive electrochemical biosensor for rapid detection of ctDNA in whole blood. The sensing of ctDNA is based on hybridization on a network of probe DNA modified gold-coate ...[more]