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Anthelmintics for drug repurposing: Opportunities and challenges.

ABSTRACT: Drug repositioning is defined as a process to identify a new application for drugs. This approach is critical as it takes advantage of well-known pharmacokinetics, pharmacodynamics, and toxicity profiles of the drugs; thus, the chance of their future failure decreases, and the cost of their development and the required time for their approval are reduced. Anthelmintics, which are antiparasitic drugs, have recently demonstrated promising anticancer effects in vitro and in vivo. This literature review focuses on the potential of anthelmintics for repositioning in the treatment of cancers. It also discusses their pharmacokinetics and pharmacodynamics as antiparasitic drugs, proposed anticancer mechanisms, present development conditions, challenges in cancer therapy, and strategies to overcome these challenges.

SUBMITTER: Alavi SE

PROVIDER: S-EPMC8180459 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature

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Anthelmintics for drug repurposing: Opportunities and challenges.

Alavi Seyed Ebrahim SE Ebrahimi Shahmabadi Hasan H

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society 20210416 5

Drug repositioning is defined as a process to identify a new application for drugs. This approach is critical as it takes advantage of well-known pharmacokinetics, pharmacodynamics, and toxicity profiles of the drugs; thus, the chance of their future failure decreases, and the cost of their development and the required time for their approval are reduced. Anthelmintics, which are antiparasitic drugs, have recently demonstrated promising anticancer effects <i>in vitro</i> and <i>in vivo</i>. This ...[more]

PMID: 34135669

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