Cell entry by SARS-CoV-2.
Ontology highlight
ABSTRACT:
SUBMITTER: Peng R
PROVIDER: S-EPMC8180548 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
Cell entry by SARS-CoV-2.
Peng Ruchao R Wu Lian-Ao LA Wang Qingling Q Qi Jianxun J Gao George Fu GF
Trends in biochemical sciences 20210607 10
Severe acute respiratory syndrome virus 2 (SARS-CoV-2) invades host cells by interacting with receptors/coreceptors, as well as with other cofactors, via its spike (S) protein that further mediates fusion between viral and cellular membranes. The host membrane protein, angiotensin-converting enzyme 2 (ACE2), is the major receptor for SARS-CoV-2 and is a crucial determinant for cross-species transmission. In addition, some auxiliary receptors and cofactors are also involved that expand the host/t ...[more]
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