Alterations in the Gut Microbiome of Infants Consuming Partially Hydrolyzed Cow Milk Protein Formula

ABSTRACT: Abstract

Objectives

The first year of life is a critical window for appropriate enteric microbiome development. Variations in infant diets have persistent effects on gut microbial ecology. Compared to intact protein formulas (IPF), partially hydrolyzed infant formulas (PHF) contain broken down milk proteins and may impact development of atopic conditions in high-risk infants. However, the effects of PHFs on the developing gut microbiome are not known.

Methods

This study was a secondary analysis of the GLOWING study (ClinicalTrials.gov NCT01131117). Infant stool samples were collected at 6 months of age and microbial composition was examined via 16S rRNA amplicon sequencing (V4 region) using standardized methods. Samples were grouped by primary feeding type: Exclusive brea

SUBMITTER:  

PROVIDER: S-EPMC8181719 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature