Pharmacokinetics of Orally Administered GS-441524 in Dogs.
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ABSTRACT:
SUBMITTER: Yan VC
PROVIDER: S-EPMC8183013 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Publications
Pharmacokinetics of Orally Administered GS-441524 in Dogs.
Yan Victoria C VC Pham Cong-Dat CD Yan Matthew J MJ Yan Alexander J AJ Khadka Sunada S Arthur Kenisha K Ackroyd Jeffrey J JJ Georgiou Dimitra K DK Roon Laura E LE Bushman Lane R LR Anderson Peter L PL Li Chun C Muller Florian L FL
bioRxiv : the preprint server for biology 20210531
Despite being FDA-approved for COVID-19, the clinical efficacy of remdesivir (Veklury<sup>®</sup>) remains contentious. We previously pointed out pharmacokinetic, pharmacodynamic and toxicology reasons for why its parent nucleoside GS-441524, is better suited for COVID-19 treatment. Here, we assess the oral bioavailability of GS-441524 in beagle dogs and show that plasma concentrations ~24-fold higher than the EC<sub>50</sub> against SARS-CoV-2 are easily and safely sustained. These data support ...[more]
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