Ontology highlight
ABSTRACT:
SUBMITTER: Wei D
PROVIDER: S-EPMC8354861 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Wei Daibao D Hu Tianwen T Zhang Yumin Y Zheng Wei W Xue Haitao H Shen Jingshan J Xie Yuanchao Y Aisa Haji A HA
Bioorganic & medicinal chemistry 20210811
The nucleoside metabolite of remdesivir, GS-441524 displays potent anti-SARS-CoV-2 efficacy, and is being evaluated in clinical as an oral antiviral therapeutic for COVID-19. However, this nucleoside has a poor oral bioavailability in non-human primates, which may affect its therapeutic efficacy. Herein, we reported a variety of GS-441524 analogs with modifications on the base or the sugar moiety, as well as some prodrug forms, including five isobutyryl esters, two l-valine esters, and one carba ...[more]