Relationship between microsatellite status and immune microenvironment of colorectal cancer and its application to diagnosis and treatment.

ABSTRACT: Due to advances in understanding the immune microenvironment of colorectal cancer (CRC), microsatellite classification (dMMR/MSI-H and pMMR/MSS) has become a key biomarker for the diagnosis and treatment of CRC patients and therefore has important clinical value. Microsatellite status is associated with a variety of clinicopathological features and affects drug resistance and the prognosis of patients. CRC patients with different microsatellite statuses have different compositions and distributions of immune cells and cytokines within their tumor microenvironments (TMEs). Therefore, there is great interest in reversing or reshaping CRC TMEs to transform immune tolerant "cold" tumors into immune sensitive "hot" tumors. This requires a thorough understanding of differences in the immune micr

SUBMITTER: Bai J 

PROVIDER: S-EPMC8183910 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature