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Melatonin in Early Treatment for COVID-19: A Narrative Review of Current Evidence and Possible Efficacy.

ABSTRACT:

Objective

To date, there are no FDA approved medications for treatment of early COVID-19 infection. Recently, use of melatonin, a naturally occurring tryptophan-derivative synthesized in the pineal gland and immune cells, has been suggested as an early treatment option for COVID-19. Melatonin has known anti-inflammatory, immunomodulatory, and protective antioxidant mechanisms that may attenuate the severity of COVID-19 symptoms. The objective of the present narrative review is to discuss the use of melatonin as an early treatment option on the first day of diagnosis for COVID-19.

Methods

The MeSH terms "COVID-19" and "viral diseases" were manually searched on PubMed and relevant articles were included.

Results

Results showed that melatonin acts to reduce reactive-oxygen-species mediated damage, cytokine-induced inflammation, and lymphopenia in viral diseases similar to COVID-19.

Conclusions

These conclusions provide evidence for potential benefits in melatonin use for COVID-19 treatment as early as the day of diagnosis.

SUBMITTER: Cross KM

PROVIDER: S-EPMC8190272 | biostudies-literature |

REPOSITORIES: biostudies-literature

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