Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.
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ABSTRACT:
SUBMITTER: Zhu W
PROVIDER: S-EPMC8192646 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
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Cortical and Subcortical Grey Matter Abnormalities in White Matter Hyperintensities and Subsequent Cognitive Impairment.
Zhu Wenhao W Huang Hao H Yang Shiqi S Luo Xiang X Zhu Wenzhen W Xu Shabei S Meng Qi Q Zuo Chengchao C Liu Yong Y Wang Wei W
Neuroscience bulletin 20210407 6
Grey matter (GM) alterations may contribute to cognitive decline in individuals with white matter hyperintensities (WMH) but no consensus has yet emerged. Here, we investigated cortical thickness and grey matter volume in 23 WMH patients with mild cognitive impairment (WMH-MCI), 43 WMH patients without cognitive impairment, and 55 healthy controls. Both WMH groups showed GM atrophy in the bilateral thalamus, fronto-insular cortices, and several parietal-temporal regions, and the WMH-MCI group sh ...[more]
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