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I(nsp1)ecting SARS-CoV-2-ribosome interactions.

ABSTRACT: While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different scenarios potentially explaining how the viral RNA can bypass its own translation blockage and speculate on the suitability of Nsp1 as a therapeutic target.

SUBMITTER: Simeoni M

PROVIDER: S-EPMC8192748 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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I(nsp1)ecting SARS-CoV-2-ribosome interactions.

Simeoni Matthieu M Cavinato Théo T Rodriguez Daniel D Gatfield David D

Communications biology 20210610 1

While SARS-CoV-2 is causing modern human history's most serious health crisis and upending our way of life, clinical and basic research on the virus is advancing rapidly, leading to fascinating discoveries. Two studies have revealed how the viral virulence factor, nonstructural protein 1 (Nsp1), binds human ribosomes to inhibit host cell translation. Here, we examine the main conclusions on the molecular activity of Nsp1 and its role in suppressing innate immune responses. We discuss different s ...[more]

PMID: 34112887

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SARS-CoV-2 NSP1 induces mRNA cleavages on the ribosome.

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Project description: Not available

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