Ontology highlight
ABSTRACT:
SUBMITTER: Meier AF
PROVIDER: S-EPMC8195378 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Meier Anita Felicitas AF Tobler Kurt K Leisi Remo R Lkharrazi Anouk A Ros Carlos C Fraefel Cornel C
PLoS pathogens 20210601 6
Adeno-associated virus (AAV) genome replication only occurs in the presence of a co-infecting helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV-1). AdV5-supported replication of the AAV genome has been described to occur in a strand-displacement rolling hairpin replication (RHR) mechanism initiated at the AAV 3' inverted terminal repeat (ITR) end. It has been assumed that the same mechanism applies to HSV-1-supported AAV genome replication. Using Southern analysis ...[more]