Dataset Information

Associations of long-term exposure to environmental noise and outdoor light at night with age at natural menopause in a US women cohort.

ABSTRACT: Previous studies have suggested noise, especially at night time, and light at night (LAN) could cause neuroendocrine disturbance and circadian disruption, which may lead to ovarian follicle atresia and earlier onset of menopause. However, no study to date has directly investigated the associations of exposure to these factors and menopausal age.

Methods

Premenopausal women from the Nurses' Health Study II (NHS II) were followed from age 40 through 2015. Median daytime and nighttime anthropogenic noise and outdoor LAN exposure were measured from a geospatial prediction model and satellite images, respectively, at residential addresses throughout the follow-up. Time-varying Cox proportional hazard models were used to calculate the hazard ratios and 95% confidence intervals, adjusting for individual lifestyle, reproductive history, and neighborhood socioeconomic factors. Possible effect modification by region, smoking status, body mass index, race/ethnicity, history of rotating shift work, and census tract population density and median income was examined.

Results

A total of 63,380 of 105,326 women self-reported natural menopause during 1,043,298 person-years of follow-up. No associations were found for noise (both daytime and nighttime) and outdoor LAN exposure with age at natural menopause (hazard ratios = 0.99-1.00) in the fully adjusted models. Sensitivity analyses showed similar null associations. No meaningful effect modification was found for region, smoking status, body mass index, race/ethnicity, history of rotating shift work, and census tract socioeconomic measures in stratified analyses.

Conclusion

No associations were found between environmental noise and outdoor LAN exposure in mid-adulthood and menopausal age in this cohort of US women.

SUBMITTER: Li H

PROVIDER: S-EPMC8196097 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature

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Publications

Associations of long-term exposure to environmental noise and outdoor light at night with age at natural menopause in a US women cohort.

Li Huichu H Hart Jaime E JE Mahalingaiah Shruthi S Nethery Rachel C RC James Peter P Bertone-Johnson Elizabeth E Schernhammer Eva E Laden Francine F

Environmental epidemiology (Philadelphia, Pa.) 20210505 3

Previous studies have suggested noise, especially at night time, and light at night (LAN) could cause neuroendocrine disturbance and circadian disruption, which may lead to ovarian follicle atresia and earlier onset of menopause. However, no study to date has directly investigated the associations of exposure to these factors and menopausal age.<h4>Methods</h4>Premenopausal women from the Nurses' Health Study II (NHS II) were followed from age 40 through 2015. Median daytime and nighttime anthro ...[more]

PMID: 34131615

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Project description:ImportanceHealthy sleep has an important role in the physical and mental health of children. However, few studies have investigated the association between outdoor artificial light at night (ALAN) and sleep disorders in children.ObjectiveTo explore the associations between outdoor ALAN exposure and sleep disorders in children.Design, setting, and participantsThis population-based cross-sectional study, part of the National Chinese Children Health Study, was conducted from April 1, 2012, to June 30, 2013, in the first stage and from May 1, 2016, to May 31, 2018, in the second stage in 55 districts of 14 cities in China. This analysis included 201 994 children and adolescents aged 2 to 18 years. Data were analyzed from February 20 to March 21, 2022.ExposuresOutdoor ALAN exposure (in nanowatts per centimeters squared per steradian) within 500 m of each participant's residential address obtained from the satellite imagery data, with a resolution of approximately 500 m.Main outcomes and measuresSleep disorders were measured by the Chinese version of the Sleep Disturbance Scale for Children. Generalized linear mixed models were used to estimate the associations of outdoor ALAN with sleep scores and sleep disorders.ResultsThe study included 201 994 children and adolescents (mean [SD] age, 11.3 [3.2] years; 106 378 boys [52.7%]), 7166 (3.5%) of whom had sleep disorder symptoms. Outdoor ALAN exposure of study participants ranged from 0.02 to 113.48 nW/cm2/sr. Compared with the lowest quintile (Q1) of outdoor ALAN exposure, higher quintiles of exposure (Q2-Q5) were associated with an increase in total sleep scores of 0.81 (95% CI, 0.66-0.96) in Q2, 0.83 (95% CI, 0.68-0.97) in Q3, 0.62 (95% CI, 0.46-0.77) in Q4, and 0.53 (95% CI, 0.36-0.70) in Q5. Higher quintiles of exposure were also associated with odds ratios for sleep disorder of 1.34 (95% CI, 1.23-1.45) in Q2, 1.43 (95% CI, 1.32-1.55) in Q3, 1.31 (95% CI, 1.21-1.43) in Q4, and 1.25 (95% CI, 1.14-1.38) in Q5. Similar associations were observed for sleep disorder subtypes. In addition, greater effect estimates were found among children younger than 12 years.Conclusions and relevanceThe findings of this cross-sectional study suggest that sleep disorders are more prevalent among children residing in areas with high levels of outdoor ALAN and the associations are generally stronger in children younger than 12 years. These findings further suggest that effective control of outdoor ALAN may be an important measure for improving the quality of children's sleep.

Project description:ImportanceUnderstanding the outcomes of artificial light at night (ALAN) on insomnia is crucial for public health, particularly in rapidly urbanizing regions. However, evidence of the association between ALAN exposure and insomnia is limited, despite the large number of people exposed to ALAN.ObjectiveTo explore the association between outdoor ALAN exposure and insomnia among the Chinese population.Design, setting, and participantsThis cross-sectional study used social media data from Weibo (Sina), a social media platform, and satellite-derived nighttime light images. The study period spans from May 2022 to April 2023. The study encompasses 336 cities across China's mainland, providing a comprehensive national perspective. Data include insomnia-related posts from the platform users, representing a large and diverse population sample exposed to varying levels of ALAN.ExposureOutdoor ALAN exposure (in nanowatts per centimeters squared per steradian [nW/cm2/sr]) was measured using satellite-derived nighttime light images at a spatial resolution of 500 m.Main outcomes and measuresThe incidence of insomnia among residents at the city level was measured by the number of insomnia-related posts on social media. Multiple linear regression models were used to estimate the association between ALAN exposure and population insomnia, adjusting for population characteristics and meteorological factors at the city level.ResultsThe study included data from 1 147 583 insomnia-related posts. Daily mean ALAN exposure across the 336 cities ranged from 3.1 to 221.0 nW/cm2/sr. For each 5 nW/cm2/sr increase in ALAN exposure, the incidence of insomnia increased by 0.377% (95% CI, 0.372%-0.382%). The association was greater in less populated cities and under extreme temperature and poor air quality conditions. The observed exposure-response functions between ALAN exposure and insomnia demonstrated an upward trend, with steeper slopes observed at low exposures and leveling off at higher exposures.Conclusions and relevanceThis study provides evidence of the association between increased ALAN exposure and higher incidence of insomnia. These findings expand the current knowledge on adverse health outcomes of ALAN exposure and emphasize the potential health benefits of well-planned artificial nighttime lighting in China and other developing countries in the early stages of city planning.

Project description:BackgroundAnimal and epidemiologic studies suggest that exposure to light at night (LAN) may disrupt circadian patterns and decrease nocturnal secretion of melatonin, which may disturb estrogen regulation, leading to increased breast cancer risk.ObjectivesWe examined the association between residential outdoor LAN and breast cancer incidence using data from the nationwide U.S.-based Nurses' Health Study II cohort.MethodsWe followed 109,672 women from 1989 through 2013. Cumulative LAN exposure was estimated using time-varying satellite data for a composite of persistent nighttime illumination at ∼1 km2 scale for each residence during follow-up. Incident invasive breast cancer cases were confirmed by medical record review. We used Cox proportional hazard models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs), adjusting for anthropometric, reproductive, lifestyle, and socioeconomic risk factors.ResultsOver 2,187,425 person-years, we identified 3,549 incident breast cancer cases. Based on a fully adjusted model, the estimated HR for incident breast cancer with an interquartile range (IQR) (31.6 nW/cm2/sr) increase in cumulative average outdoor LAN was 1.05 (95% CI: 1.00, 1.11). An association between LAN and breast cancer appeared to be limited to women who were premenopausal at the time of a case [HR=1.07 (95% CI: 1.01, 1.14) based on 1,973 cases vs. HR=1.00 (95% CI: 0.91, 1.09) based on 1,172 cases in postmenopausal women; p-interaction=0.08]. The LAN-breast cancer association was observed only in past and current smokers at the end of follow-up [HR=1.00 (95% CI: 0.94, 1.07) based on 2,215 cases in never smokers; HR=1.10 (95% CI: 1.01, 1.19) based on 1,034 cases in past smokers vs. HR=1.21 (95% CI: 1.07, 1.37) for 300 cases in current smokers; p-interaction=0.08].ConclusionsAlthough further work is required to confirm our results and to clarify potential mechanisms, our findings suggest that exposure to residential outdoor light at night may contribute to invasive breast cancer risk. https://doi.org/10.1289/EHP935.

Dataset Information

Associations of long-term exposure to environmental noise and outdoor light at night with age at natural menopause in a US women cohort.

Methods

Results

Conclusion

Publications

Associations of long-term exposure to environmental noise and outdoor light at night with age at natural menopause in a US women cohort.

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