Ontology highlight
ABSTRACT:
SUBMITTER: Scheibenbogen C
PROVIDER: S-EPMC8198960 | biostudies-literature | 2021 May
REPOSITORIES: biostudies-literature
Scheibenbogen Carmen C Sotzny Franziska F Hartwig Jelka J Bauer Sandra S Freitag Helma H Wittke Kirsten K Doehner Wolfram W Scherbakov Nadja N Loebel Madlen M Grabowski Patricia P
Journal of clinical medicine 20210529 11
<h4>Background</h4>Chronic fatigue syndrome (ME/CFS) is a complex disease frequently triggered by infections. IgG substitution may have therapeutic effect both by ameliorating susceptibility to infections and due to immunomodulatory effects.<h4>Methods</h4>We conducted a proof of concept open trial with s.c. IgG in 17 ME/CFS patients suffering from recurrent infections and mild IgG or IgG subclass deficiency to assess tolerability and efficacy. Patients received s.c. IgG therapy of 0.8 g/kg/mont ...[more]