Association of Circadian Clock Gene Expression with Glioma Tumor Microenvironment and Patient Survival.

ABSTRACT: Circadian clock genes have been linked to clinical outcomes in cancer, including gliomas. However, these studies have not accounted for established markers that predict the prognosis, including mutations in Isocitrate Dehydrogenase (IDH), which characterize the majority of lower-grade gliomas and secondary high-grade gliomas. To demonstrate the connection between circadian clock genes and glioma outcomes while accounting for the IDH mutational status, we analyzed multiple publicly available gene expression datasets. The unsupervised clustering of 13 clock gene transcriptomic signatures from The Cancer Genome Atlas showed distinct molecular subtypes representing different disease states and showed the differential prognosis of these groups by a Kaplan-Meier analysis. Further a

SUBMITTER: De La Cruz Minyety J 

PROVIDER: S-EPMC8199552 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature