RNAmining: A machine learning stand-alone and web server tool for RNA coding potential prediction.

ABSTRACT: Non-coding RNAs (ncRNAs) are important players in the cellular regulation of organisms from different kingdoms. One of the key steps in ncRNAs research is the ability to distinguish coding/non-coding sequences. We applied seven machine learning algorithms (Naive Bayes, Support Vector Machine, K-Nearest Neighbors, Random Forest, Extreme Gradient Boosting, Neural Networks and Deep Learning) through model organisms from different evolutionary branches to create a stand-alone and web server tool (RNAmining) to distinguish coding and non-coding sequences. Firstly, we used coding/non-coding sequences downloaded from Ensembl (April 14th, 2020). Then, coding/non-coding sequences were balanced, had their trinucleotides count analysed (64 features) and we performed a normalization by the sequence le

SUBMITTER: Ramos TAR 

PROVIDER: S-EPMC8201426 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature