Ontology highlight
ABSTRACT:
SUBMITTER: Guo Y
PROVIDER: S-EPMC8210434 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Guo Yanghui Y Huang Xiangui X Liao Weiwei W Meng Lichen L Xu Daiwang D Ye Cheng C Chen Lei L Hu Taishan T
ACS omega 20210528 23
The angiotensin II type 2 receptor (AT<sub>2</sub>R) has attracted much attention as a potential target for the relief of neuropathic pain, which represents an area of unmet clinical need. A series of 1,2,3,4-tetrahydroisoquinolines with a benzoxazole side-chain were discovered as potent AT<sub>2</sub>R antagonists. Rational optimization resulted in compound <b>15</b>, which demonstrated both excellent antagonistic activity against AT<sub>2</sub>R <i>in vitro</i> and analgesic efficacy in a rat ...[more]