Ontology highlight
ABSTRACT:
SUBMITTER: Basu S
PROVIDER: S-EPMC5554908 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
ACS medicinal chemistry letters 20170705 8
Adenosine A<sub>2A</sub> receptor (A<sub>2A</sub>AdoR) antagonism is a nondopaminergic approach to Parkinson's disease treatment that is under development. Earlier we had reported the therapeutic potential of 7-methoxy-4-morpholino-benzothiazole derivatives as A<sub>2A</sub>AdoR antagonists. We herein described a novel series of [1,2,4]triazolo[5,1-<i>f</i>]purin-2-one derivatives that displays functional antagonism of the A<sub>2A</sub> receptor with a high degree of selectivity over A<sub>1</s ...[more]