Ontology highlight
ABSTRACT:
SUBMITTER: Tan SH
PROVIDER: S-EPMC8212351 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Tan Shi Hao SH Leong Wei Zhong WZ Ngoc Phuong Cao Thi PCT Tan Tze King TK Bertulfo Fatima Carla FC Lim Mei Chee MC An Omer O Li Zhenhua Z Yeoh Allen Eng Juh AEJ Fullwood Melissa J MJ Tenen Daniel G DG Sanda Takaomi T
Blood 20190510 3
The oncogenic transcription factor TAL1 regulates the transcriptional program in T-ALL. ARID5B is one of the critical downstream targets of TAL1, which further activates the oncogenic regulatory circuit in T-ALL cells. Here, we elucidated the molecular functions of the noncoding RNA, ARID5B-inducing enhancer associated long noncoding RNA (<i>ARIEL</i>), in T-ALL pathogenesis. We demonstrated that <i>ARIEL</i> is specifically activated in <i>TAL1</i> <sup>+</sup> T-ALL cases, and its expression i ...[more]